Ajax Harwood Clinic
4-point saliva cortisol test
Full name: Diurnal salivary cortisol panel (4-point / "adrenal stress")
This test doesn't have a proven medical use for the reasons people usually ask about it.
What this test is
This test collects saliva four or more times in one day to draw a curve of your cortisol, a stress hormone. It is sometimes called an 'adrenal stress' test. It is often used to explain tiredness, poor sleep or stress. Researchers have studied these cortisol curves many times, and the results have not agreed with each other. So a 'flat' or 'high' curve does not reliably tell us what is wrong or what to do. 'Adrenal fatigue' is not a recognized medical diagnosis. Your tiredness is real, though, and worth looking into. Your doctor can check for common causes like poor sleep, low iron, thyroid problems, or low mood.
Want to see the full clinical reasoning? The reference we use for this test is open to anyone — it is detailed and written for clinicians, and you are welcome to read it.
Open the clinician reference →Looking for other tests, or more on a condition an ND raised? Explore ask.ajaxharwoodclinic.com →
General health information for Ajax Harwood Clinic patients and the public — not medical advice, and not a substitute for seeing your own doctor. Last reviewed 2026-09-23.